The mission of the Yscript consortium is to lay the foundations for low-cost, large-scale production of mRNA drugs and vaccines by building a customised mRNA factory platform using yeast. Messenger RNA vaccines have decisively changed the fight against COVID-19, and mRNA is considered the basis for a wide range of therapeutic applications.
Currently, however, the only available technology for mRNA production is highly complex and expensive. These restrictions hinder large-scale mRNA production and are especially a problem for low-income countries. Yscript is working with eight partners from five countries to develop a specific mRNA bioproduction and purification process in yeast that overcomes this obstacle. Low production costs and viable supply chains could thus enable mRNA-based therapeutics to effectively combat diseases and epidemics worldwide.